Three Common Variants of <i>LEP, NPY1R </i>and<i> GPR54</i> Show No Association with Age at Menarche
نویسندگان
چکیده
منابع مشابه
No association between age at menarche and sex of offspring.
Sir, We read with interest the article by Fukuda et al. (2011). The title ‘The sex ratio of offspring is associated with the mothers’ age at menarche’ suggests a direct connection between age at menarche and sex of offspring. We consider this interpretation a stretch of the presented data and want to comment on some issues in their study. Additionally, results from our substantially larger Dani...
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More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2009
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000223417